Presented at the Purdue Process Safety Assurance Center's Spring Conference in May 2022, this presentation delves into the lessons learned from the explosion of August 4, 2020, one of the largest industrial accidents in history. The impacts to an entire nation from a single industrial accident may be incomparable considering fatalities, injuries, and the economic impacts to GDP and public disruption to a major capital city and global nation. Lessons learned have widespread implications for facility siting and public risk management, handling of oxidizers, the management of chemicals in storage and transportation, and emergency management for large-scale emergencies.